Lorenzo Leggio Selected Research

Baclofen

12/2021	The GABA-B receptor agonist baclofen helps patients with alcohol use disorder: why these findings matter.
1/2021	A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation.
1/2021	The influence of anxiety symptoms on clinical outcomes during baclofen treatment of alcohol use disorder: A systematic review and meta-analysis.
12/2018	Baclofen for the treatment of alcohol use disorder: the Cagliari Statement.
1/2018	The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective.
1/2018	Neuroendocrine response to GABA-B receptor agonism in alcohol-dependent individuals: Results from a combined outpatient and human laboratory experiment.
1/2018	Baclofen in the Treatment of Patients With Alcohol Use Disorder and Other Mental Health Disorders.
5/2015	T76. Baclofen as a pharmacotherapy for the treatment of concurrent alcohol and nicotine dependence: a double-blind, placebo-controlled, randomized trial.
1/2015	A preliminary double-blind, placebo-controlled randomized study of baclofen effects in alcoholic smokers.
4/2013	Management of alcohol dependence in patients with liver disease.

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Lorenzo Leggio Research Topics

Disease

92	Alcoholism (Alcohol Abuse) 01/2022 - 08/2006
7	Mental Disorders (Mental Disorder) 01/2021 - 01/2012
6	Obesity 01/2021 - 01/2017
6	Substance Withdrawal Syndrome (Withdrawal Symptoms) 06/2010 - 09/2003
5	Fibrosis (Cirrhosis) 01/2022 - 01/2006
5	Substance-Related Disorders (Drug Abuse) 01/2019 - 01/2012
5	Liver Diseases (Liver Disease) 01/2018 - 11/2009
4	Liver Cirrhosis (Hepatic Cirrhosis) 04/2013 - 12/2007
3	Weight Loss (Weight Reduction) 01/2019 - 01/2015
2	Tobacco Use Disorder (Nicotine Dependence) 01/2021 - 05/2015
2	Mood Disorders (Mood Disorder) 01/2021 - 01/2018
2	Neoplasms (Cancer) 01/2021 - 05/2009
2	Inflammation (Inflammations) 01/2020 - 01/2011
2	Body Weight (Weight, Body) 10/2019 - 01/2019
2	Morbid Obesity 01/2019 - 01/2013
2	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2017 - 01/2012
2	Alcoholic Liver Diseases (Alcoholic Liver Disease) 08/2014 - 12/2011
2	Alcoholic Hepatitis 08/2014 - 07/2009
2	Celiac Disease (Celiac Sprue) 11/2009 - 01/2008
2	Hepatolenticular Degeneration (Wilson's Disease) 10/2007 - 01/2006
2	Alcohol Withdrawal Delirium (Delirium Tremens) 03/2005 - 09/2003
1	Opioid-Related Disorders (Opiate Addiction) 01/2022
1	Sleepiness 01/2021
1	Sleep Wake Disorders 01/2021
1	Narcolepsy 01/2021
1	Anxiety Disorders (Anxiety Disorder) 04/2020
1	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2020
1	Multiple Endocrine Neoplasia Type 2b (MEN 3) 01/2020
1	Weight Gain 12/2019
1	Cancer Pain 10/2019
1	Acute Pain 10/2019
1	Chronic Pain 10/2019
1	Pain (Aches) 10/2019

Drug/Important Bio-Agent (IBA)

21	Baclofen FDA LinkGeneric 12/2021 - 09/2003
19	GhrelinIBA 01/2022 - 11/2006
12	Pharmaceutical PreparationsIBA 01/2022 - 03/2006
8	Ghrelin ReceptorsIBA 01/2022 - 07/2015
6	Biological ProductsIBA 01/2021 - 01/2010
6	Hormones (Hormone)IBA 11/2019 - 08/2008
6	Disulfiram (Antabuse)FDA Link 01/2018 - 09/2012
5	LeptinIBA 01/2021 - 05/2009
5	Naltrexone (ReVia)FDA LinkGeneric 01/2018 - 11/2013
5	Acamprosate (Campral)FDA Link 01/2018 - 09/2012
4	GABA-B Receptor AgonistsIBA 12/2021 - 03/2010
4	Oxytocin (Pitocin)FDA LinkGeneric 01/2021 - 02/2016
4	PF-5190457IBA 01/2021 - 07/2015
4	Cocaine (Cocaine HCl)IBA 12/2019 - 02/2016
4	gamma-Aminobutyric Acid (GABA)IBA 01/2019 - 01/2011
4	Topiramate (Topamax)FDA LinkGeneric 05/2018 - 05/2009
4	GABA-B ReceptorsIBA 01/2018 - 07/2009
4	Peptides (Polypeptides)IBA 11/2017 - 03/2009
3	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 01/2022 - 11/2017
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 06/2012
3	Insulin (Novolin)FDA Link 09/2018 - 05/2009
3	Prazosin (Minipress)FDA LinkGeneric 01/2017 - 01/2013
3	Doxazosin (Cardura)FDA LinkGeneric 01/2017 - 01/2013
2	Thiamine (Aneurin)FDA Link 11/2021 - 07/2014
2	Dopamine (Intropin)FDA LinkGeneric 01/2021 - 01/2020
2	CholesterolIBA 01/2021 - 10/2007
2	TransferasesIBA 01/2021 - 01/2017
2	Triglycerides (Triacylglycerol)IBA 01/2021 - 01/2017
2	Opioid Analgesics (Opioids)IBA 10/2019 - 11/2012
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2018 - 01/2016
2	EnzymesIBA 01/2017 - 09/2015
2	LipidsIBA 01/2017 - 11/2009
2	Pentoxifylline (Trental)FDA LinkGeneric 08/2014 - 07/2009
2	Glutens (Glutelin)IBA 01/2008 - 10/2007
1	fibroblast growth factor 21IBA 01/2022
1	AcyltransferasesIBA 01/2022
1	Oxycodone (Oxycontin)FDA LinkGeneric 01/2022
1	alpha-Tocopherol FDA Link 01/2021
1	EndorphinsIBA 01/2021
1	CotinineIBA 01/2021
1	Modafinil (Provigil)FDA Link 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	beta Carotene (Betacarotene)FDA Link 01/2021
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2021
1	Substance PIBA 01/2021
1	OrexinsIBA 01/2021
1	Leptin ReceptorsIBA 01/2021
1	MelatoninIBA 01/2021
1	Melanocyte-Stimulating Hormones (MSH)IBA 01/2021
1	Therapeutic UsesIBA 01/2021
1	Glucagon-Like Peptide-1 Receptor AgonistsIBA 01/2020
1	acyl-ghrelinIBA 12/2019
1	AntibodiesIBA 12/2019
1	ProdrugsIBA 01/2019
1	1- (((alpha- isobutanoyloxyethoxy)carbonyl)aminomethyl)- 1- cyclohexaneacetic acidIBA 01/2019

Therapy/Procedure

21	Drug Therapy (Chemotherapy) 01/2022 - 05/2009
4	Therapeutics 01/2022 - 01/2003
4	Gluten-Free Diet 11/2009 - 01/2003
3	Liver Transplantation 01/2022 - 09/2013
2	Transplantation 01/2022 - 09/2013
2	Bariatric Surgery 01/2019 - 11/2017
2	Transcranial Magnetic Stimulation 09/2018 - 01/2012
2	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2015 - 01/2013
2	Complementary Therapies (Alternative Medicine) 02/2008 - 08/2006
1	Off-Label Use 01/2021
1	Self Administration (Administration, Self) 01/2020
1	Patient-Controlled Analgesia (Analgesia, Patient Controlled) 10/2019